• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The invention relates to biotechnology and relates to the treatment of an aqueous solution of heteropolysaccharide, which can be used in the processes of secondary and tertiary recovery of oil. The aim of the invention is to improve the quality of the treatment by improving the physicochemical properties of the solution. The method consists in that the culture fluid of Xanthomonas campestris is subjected to enzymatic treatment with Novozym 234, which contains a balanced ratio of different types of hydrolytic enzymes. At the same time, before the introduction of the enzyme preparation, the culture fluid is preliminary; - warm up. The resulting solution has the best filterability, transparency and injectability. 5 tab. g
    公开号:SU1429938A3
    申请号:SU843785901
    申请日:1984-08-29
    公开日:1988-10-07
    发明作者:Гозар Жан-Пьер；Жарри Алэн；Люссиони Алэн
    申请人:Рон-Пуленк Спесьялитэ Шимик (Фирма)；
    IPC主号:
    专利说明:

    i The invention relates to biotechnology and is related to the treatment of an aqueous solution of a heteropolysaccharide, which: can be used in the processes of secondary and tertiary recovery of oil.
    The purpose of the invention is to improve the quality of processing by improving the physicochemical properties of the solution. ; Polysaccharide solutions, which are hydrophilic colloids, are obtained by fermenting bacteria of the species Xanthomonas campestris j on carbohydrate raw materials. Suitable for (use of carbohydrates for this purpose; glucose, sucrose, frostose, maltose, lactose, starch. The carbohydrate is usually harvested in an aqueous medium containing up to 100 g / l of carbohydrate. The fermentation medium can also , contain a source of phosphorus, a source of magnesium, which is an activator of enzymes, and a source of nitrogen, which can be organic, mineral, or mixed, organic-mineral origin.
    As a result of the fermentation process and polysaccharide production, the culture liquid (wort) usually contains about 15-50 grams per liter of polymer, as well as various components, including bacterial cells, cell debris, residual proteins, and mineral ions.
    The biopolymer can be removed from the wort by sedimentation with a precipitating agent, for example isopropanol, filtration and drying.
    The method according to the invention can be applied to solutions obtained by diluting a commercial biopolymer in a powder, however, it is most expedient for further use in oil recovery. use culture liquid.
    The mutant-containing enzyme is added to an aqueous solution containing 0.15 to 30 wt.% Polysaccharide, and the mixture is held with or without stirring.
    at a temperature of from ambient temperature to 60 ° C, preferably 25 to 55 ° C, in tons (4 to 24 hours or more at a pH of 3.5 to 7. It is advisable to set the pH to 4 to 5.8 by adding mineral or organic acids, such as sulfuric, phosphoric, nitric, acetic, formic.
    d 0 5
    0
    Q 5
    0
    five
    If the solution to be treated is prepared — from isolated from bro. dylnogo mash powder, it is advisable that the concentration of the polysaccharide was 0.25-1.5%.
    If whole fermented wort is processed, the concentration of the polysaccharide is usually between 1.5 and 20% by weight. The whole wort may be a product directly obtained by fermentation, in which case the concentration is 1.5-5%. Or it may be a wort concentrated by traditional methods to a polysaccharide content of about 20%.
    The method of processing polysaccharide solutions involves enzymatic treatment and consists in bringing these solutions into contact with an effective amount of a complex enzyme containing mutanosis.
    Mutanoses are ceMejiCTBo enzymes, the main common feature of which is their ability to act on 1,3,3-glucosidic bonds in the alpha position. Mutanases are obtained by cultivating the corresponding microorganisms on a medium, the main source of which carbon is a mutant that is streptococcal, for example Streptococcus mutans CB S No. 350-71. Microorganisms that generate mutanases are Tri-choderma hargi arauni, Peni ci Ilium f unculosum, Penicillium melinii, Peni-clium janthinellum.
    The product containing mutanase, which is preferably used in the proposed method, is obtained from Trichoderma hargianum. The cultivation of Trichoderma hargianum is carried out in order to obtain oi -1,3-gluconase (mutanase) capable of hydrolyzing ci-1.3 glucan.
    During the enzymatic microbial
    with
    fermentation in the absence of special-opt. the most favorable conditions are given several related enzyme components at relatively constant ratios. The industrial product used according to the invention is sold under the brand name Novozym 234 by Novo Industri A./S. This enzyme exhibits, in addition to the main matanase activity, cellulose, laminarinase, xylanase, chathinase, and protein: 1 activity.
    The amount of complex enzyme.
    The solution should be sufficient to ensure the decomposition of insoluble polysaccharides. and bacterial cell debris.
    This amount simultaneously depends on the significant activity of the complex, on the content of insoluble substances in the solution to be treated, and on the conditions of the enzymatic treatment.
    When using the Novorim 234 o. Complex, an amount of 0.1–3 wt.% With respect to the weight of xanthene resin is usually sufficient. A rational amount can also be calculated with respect to nitrogen contained in the medium and coming mainly from biomass. Enzyme V-in an amount of 20150 grams, preferably 40-100 grams per 100 grams of nitrogen is usually sufficient to destroy both bacterial residues and insoluble substances of non-bacterial origin.
    Enzymatic treatment is possible. also carried out with solutions of polysaccharides, which were previously pre-vetlen by known methods, for example
    by means of pasteurization, centrifuges - JQ cartridges in which the polymer can
    filtering through diatomaceous earths, etc.
    The polysaccharide solution, which j, is a whole fermented wort, is subjected to an enzymatic treatment and heated to 60-150 ° C for 5 minutes to 2 hours. It is established that the combination of heat treatment with enzymatic treatment leads to a noticeable clarification of xanthan gum solutions. The best results from the point of view of the properties of the agent viscosity, weight and injection are obtained with the help of. heat treating the fermentation wort at pH 3.5–6.2, preferably 4– 5.5, at a temperature of 60–110 ° C, preferably 80–100 ° C, for 5–60 min, preferably 15–30 min, followed by complex enzyme treatment.
    The resulting heteropoly treatment solutions heteropoli-. saccharides, as well as powders isolated from these solutions, can be used in all cases where clarified products are required, for example, in secondary and tertiary oil recovery.
    35
    40
    45
    50
    55
    be subject to high velocity gradients (1000 10000), which significantly reduce the real viscosity of the product, which allows for: fast transportation in industrial equipment with a large surface (10-50 m) and improved transport. For this process, membrane filters can be used, for example, from cellulose, polyamide, polybenzimidazole acrylic copolymer, polyacrylonyl, polysulfone, vinylidene polyfluoride, complex complex polyelectrolytes, filtration thresholds of which are 10-100000,
    The flow rate depends on the temperature, the flow rate, the flow rate, as well as the viscosity and concentration of the biopolymer and is 5–50 lDH m) at a linear velocity of 0.5–5 m / s. The temperature can be from an ambient temperature, a medium temperature to 80 ° C, a pressure in the order of 1-15 bar, preferably 1-6 bar.
    Usually, ultrafiltration makes it possible to obtain a concentration of 70-180 g of bioplimer per kg of wort. If the complex enzyme is added to ultrafiltration, the enzymatic reaction is continued. During the polymer concentration phase
    29938
    -
    Q 15 20 25

    It is economically unprofitable to transport a weakly concentrated solution. When using a polymer in a powder, there is a problem of re-dissolution during use. In certain cases it is advisable to concentrate the solution of biopoly 5er. Concentration can be carried out using conventional techniques, for example, evaporation or ultrafiltration. The latter method is preferred because it is more economical and allows separating low and high molecular weight molecules under industrial conditions and concentrating the polymers without changing them. rheological properties. It has been established that ultrafiltration, even with a high velocity gradient, does not change the properties of the viscosity agent and the filterability of the solutions.
    Concentration by ultrafiltration may be carried out using known techniques and equipment. nor, for example, using apparatus with filter cartridges, spirals, tubes. It is preferable to use devices with corrugated filter
    five
    0
    five
    0
    five
    to be subject to high velocity gradients (1000 10000), which significantly reduce the real viscosity of the product, which allows for: fast transportation in industrial large-surface apparatus (10-50 m) and improved transport. For this process, membrane filters can be used, for example, cellulose, polyamide, polybenzimidazole, acrylic copolymer, polyacrylonitrile, polysulfone, vinylidene polyfluoride, complex complex polyelectrolytes, whose filtration thresholds are 10-100000,
    The flow rate is dependent on temperature, pressure, flow rate, as well as viscosity and concentration of the biopolymer and is 5-50 lDPH m) at a linear velocity of 0.5-5 m / s. The temperature can be from an ambient temperature, from a medium to 80 ° C, a pressure in the order of 1-15 bar, preferably 1-6 bar.
    Usually, ultrafiltration yields a concentration of 70-180 g of biopolymer per kg of wort. If the complex enzyme is added before ultrafiltration, the enzymatic reaction is continued during the polymer concentration phase.
    5.14
    It is possible to purify the polysaccharide solution using diafilBtracium by continuously or periodically adding water during or after ultrafiltration at a rate E substantially corresponding to the ultrafiltrate sampling rate. Molecules with a low molecular weight, Obtained as a result of an en- (zymotic decomposition) reaction, JB permeate is removed. The product thus purified has improved viscosity properties.
    Thermal treatment in an acidic environment in combination with enzymatic treatment allows an improvement in the ultrafiltration index in comparison with the untreated 1M thermal wort. ; or with a wort that has been subjected to treatment; treatment under conditions of neutral or alkaline pH, in particular, with the same sweat; voltage on the contacts is ultra-. (filtrate heat treatment in an acidic medium allows to obtain more concentrated solutions of biopolymers and higher costs (nutrition). Thus, a concentration of 200 and even 300 g pa of 1 kg of wort can be obtained.
    Example 1. A fermentation wort with an xantenome resin content of 8 g / l, obtained by fermenting Xanthomonas cam-: pestris, is used.
     One fraction of the wort is concentrated by ultrafiltration, using -; eu device UFP 0, equipped with membrane cartridges 1 RIS 3038 (trade marks of a foreign company to a concentration of i kg of wort.
    The pH of the second fraction is adjusted to 5.5 by adding concentrated sulfuric acid, then this fraction is heated to 5 minutes. After cooling, the wort is concentrated by ultrafiltration, like the first fraction, to a concentration of 112 g / kg.
    1.1 g of Novozyme 234 (trademark of Novo Industri A / S) was added to 1 kg of each fraction of the concentrated wort. The mixture is kept for 14 hours at 30 ° C with stirring, then cooled to ambient temperature.
    The viscosity of the solution with the
    Ron Poulenc Reshresh), 1 12g biopolit-iepa on
    f





    the concentration of xanthan gum 1000 MD, containing 5 g / l NaCl, as well as the turbidity of the solution at 1000 ppm
    Viscosity measurements are made using a Brookfield Viscometer,. equipped with an UL attachment, at 25 ° C for a shear rate of 7.3.
    Turbidity is determined by measuring the optical density at 650 nm for a 4 cm optical path.
    The results are presented in table 1.
    Processed by Novozym 234 without heat treatment 42.5 0.4 | 5
    Processed at 100 ° C, pH 3.5, then treated with Novozym 234 63, 1 O, 144
    Processed by
    pH 5.5
    not processed
    (control) 59.5 0.749
    Example 2. A broth wort containing 80 g of xanthan gum per 1 kg of wort is used, which is concentrated in an uninterrupted manner using an ultrafiltration of crude wort with a concentration of 15.6 k / kg, treated at a pH of 5.5 for 15 min at , and without heat treatment.
    1 g of Novozyme 234 is added to 1 kg of concentrated wort. The mixture is kept at 40 ° C for 14 hours with stirring, then cooled to ambient temperature.
    The processing efficiency with respect to the ability for filterability and injectability is determined by the tests described below, in comparison with the same wort, not. subject to endogenous treatment.
    The results of prehig. Stamped in table 2,
    , T a b
    a 2
    Yes
    5028.4
    (83 ml)
    3
    Her
    Not
    Clogging
    The continuous flow or filtration test allows the detection of contamination that can occur when a diluted solution of a biopolymer is injected into an oil reservoir and therefore measures the suitability of a solution of a biopolymer for use in the course of concomitant oil recovery.
    The principle of this test is that solutions with a constant pachode 4 are passed through a calibrated filter. The loss of pressure (rP) on the filter contacts caused by the passage of the biopolymer solution, characterizes its suitability for filtration.
    To meet the conditions at the site of use, the solutions are tested. , with the same viscosity (and not with the same concentration).
    The tests were carried out under the following conditions: temperature 30 ° C, flow rate 22.5 ml / h; Milli brand filters with a diameter of 47 mm, with a pore diameter of 3, 8 and 12 microns.
    Cooking solutions. The wort is diluted in water containing salt (50 g / l NaCl and 5 g / l CaC), so that the resulting solution has in s. the bone is 35 mPa-s (as measured by a Brookfield viscometer with a UL pinch at, the degree of shear is 7.3 s.
    The pressure loss of the DS is measured when the 350 solution of the solution turns out to be filtered. If the pressure exceeds 50 mbar, the number in brackets indicates the volume of the solution that was filtered when the pressure reached 50 mbar.
    (Oh, 10 ml)
    10 mn 10 tEKH iO MitH 48 s0,390
    () (450kp) (740 w)
    Zasorenpe0,860
    The constant pressure injection test allows you to set the injection properties of diluted solutions of a biopolymer. The principle is that solutions under constant pressure are passed through a calibrated filter. The volume expiring depending on time characterizes the injectability.
    The test is carried out under the following conditions: Millipore brand filters with a diameter of 47 mm and a pore diameter of 0.8-8 microns; pressure 3 bar, the preparation of solutions is identical to the preparation of solutions in the test for filterability with a constant flow rate. Viscosity is 35 mPa-s (Brookfield with UL prefix, 7.2 s-).
    Record the time spent on the flow of your solution. If this time exceeds 10 minutes, the value in brackets indicates the volume of the solution that was filtered.
    PRI, -Mer 3. The effect of enzymatic treatment on the injection of diluted solutions, obtained from xanthan gum powder, which was precipitated from the treated wort.
    From the mash processed by Novozim. 234 of Example 2, the biopolymer is precipitated by precipitation with isopropanol. The fibers are washed, dried and milled.
    For comparison, the biopolymer was isolated from the fraction of the same wort, but before
    -
    Dilute 5 g of the powder with water containing salts using a brand mixer.
    Warnip Blender so that the viscosity of the nonyenoro hormone is 35, and the salt concentration is 50 g / l KaCl n 5 g / l CaClj.
    Test solution
    Raw Wort Fiber
    Fiber must processed by Novozim 234
    An example. 20 kg of fermenting wort, containing 15.6 g of xanthene resin per 1 kg of resin, are thermally treated for 15 minutes at 100 С and pH 5.5.
    To 5 kg of the treated and cooled to 40 ° C wort, 1 g of Novits 234 is added and the solution held for 10 hours at 40 ° C. The wort is then concentrated by ultrafiltration on UFP 2 (trademark of the company Roi-Poulenc Reschersch) equipped with IRIS 3038 A membrane filters from acrylonitrile with a filtering surface of 0.022 m. The wort is concentrated to a content of 80 g per 1 kg of wort.
    100 g of wort is selected for injection testing at a constant rate.
    Each of these solutions is subjected to the constant pressure injection test described in the previous example. The results are presented in table 3.
    Table 3
    Injection at constant pressure of 3 bar - time for 1000 ml of solution to pass through 35 mPa-s through priority filters, µm
    10 min 10 min
    30 s
    (220 ml) (905 ml)
    1 min 52 s
    32 s
    19 seconds
    (580 ml)
    The remaining wort is desiccated in a known manner (diafiltration) at 55 ° C with running water in an amount 5 times the weight of the wort on the same apparatus, and then concentrated again to 80 g / kg. As the washing proceeds, the final concentration of nitrogen in the residual with the substance decreases, reaching at the end of the operation 20% of the initial content.
    - The results of the test for injection with constant flow rate are presented in Table 4 in comparison with the wort, which was concentrated by ultrafiltration without heat treatment and without significant processing (control sample).
    UF concentration
    815 35 50 44
    (22.5 ml)
    Processed by Nrvozim
    234, concentration on
    Processed by Novozyme 234, concentration on UF-, diafiltration
    Example 5, For the determination of ef.
    The effectiveness of the complex enzyme preparation Novozyme 234 compared to the enzyme preparation Kitalaz uses Kilzan xanthan gum. The xanthan gum is diluted in water containing salt and is used for the preparation of xanthan gum at 6000 ppm. Add 25 ppm of Alcalase or 25 ppm of Noxme 234. The solution containing Novozym is adjusted to pH 6 ( pH, promoting enzyme activity). Each mixture was stirred at 25 ° C for 4 hours.
    Not processed with shear without shear
    Treated Alcalas
    with a shift of 0.030 1100 3.7 3.15 without a shift of 0.033 540 3.5 3.15
    Table 4
    35.3 37
    12.1 1.7
    37.2 35.1
    11.4 1.8
    At the end of the treatment, part of the solutions are subjected to shear forces at R of about 30 bar. Each sample is diluted with USBR water for a xanthan concentration of 300 "i. ppm. The optical density is measured. The filterability is determined on a 1.2 mm filter by measuring the amount of solution filtered for 5 minutes at a pressure of 1.4 bar. Viscosity is measured by a Brookfield instrument.
    The test results are presented in table.5 ..

    200 120
    3.6
    3.5
    3.2 3.2
    Formula of invention
    A method of treating a polysaccharide containing culture liquid Haltho mpnas campefetris, involving the introduction into it of a complex enzyme — a Hijjro preparation with cellulose, 3-gluconase and. n |) otease activities, followed by imjiM incubation, I differ - and with the fact that, in order to increase the quality of processing by improving the physicochemical properties of the plant
    a thief, as a complex enzyme preparation, Novoms 234 is used, which additionally has 3-gluconase activity, which is administered in an amount of 0.1–3% by weight per 0.15–30 wt. % of the polysaccharide culture liquid, while incubation is carried out at 30-60 ° C for 4-14 hours, and before introducing the enzyme preparation on the culture liquid, it is preheated at 60-100 ° C for 5-60 minutes and set at 3.5- 6.2.
    权利要求:
    Claims (1)
    [1]
    Claim
    A method for processing a polysaccharide-containing culture fluid Xanthompnas campefetris, comprising administering a complex enzyme preparation having cellulosic, = 1, 3-gluconase and protease activities into it, followed by incubation, characterized in that, in order to improve the quality of processing by improving physico-chemical properties of the thief 3Q thief, as a complex enzyme preparation, Novo20 zim 234 is used, which has an additional ού-l, 3-gluconase activity, which is administered in an amount of 0.1-3 wt.% per 0,15-30 ISDA polysaccharide culture liquid,
    25 this incubation is carried out at 30-60 C for 4-14 hours, and before introducing the enzyme preparation on the culture fluid, it is preheated at 60-100 C for 5-60 minutes and set at 3, 5-6,2.
    类似技术:
    公开号 | 公开日 | 专利标题
    SU1429938A3|1988-10-07|Method of treating culture fluid xanthomonas campestris containing polysaccharide
    EP0145233B1|1988-06-22|Separation processfor a 3-hydroxybutyrate polymer
    US20050087497A1|2005-04-28|Separation of biomass from lactic-acid containing fermentation products by means of flocculation
    US2709150A|1955-05-24|Method of producing dextran material by bacteriological and enzymatic action
    CN113195730A|2021-07-30|Method for separating biomass from a solution comprising biomass and at least one oligosaccharide
    EP2784156B1|2017-06-14|Method for producing cellulase, and apparatus for said method
    US5994107A|1999-11-30|Process of purifying xanthan gum using an alkaline protease and lysozyme
    HU198531B|1989-10-30|Process for improving of filtring and injecting ability of watery solutions of hetero-polisacharids
    CA1174993A|1984-09-25|Clarification of polysaccharide-containingfermentation products
    US5846333A|1998-12-08|Method of producing fructose syrup from agave plants
    EP0184882B1|1989-02-01|Method for improving the filterability of a microbial broth and its use
    EP0516491A2|1992-12-02|Process for preparing pyrodextrin hydrolyzate by enzymatic hydrolysis
    KR880002534B1|1988-11-28|Theatment of polysaccharide solutions
    JP2000333692A|2000-12-05|Production of xylooligosaccharide
    JP6942406B2|2021-09-29|Separation of enzymes from Trichoderma reesei by filter press and ceramic membrane tangential filtration
    US4978750A|1990-12-18|Process for the production of heteropolysaccharides having improved properties, more especially xanthan
    EP0624651B1|2001-11-07|Xanthan gum from dairy permeates and other filtered dairy products
    KR100312638B1|2001-12-28|Method for manufacturing high purity hyaluronic acid
    CN113215210A|2021-08-06|Method for preparing sialic acid by adopting polysialic acid fermentation liquor
    KR100253423B1|2000-04-15|Process for purifying erythritol
    RU2084171C1|1997-07-20|Method of preparing autolyzed yeast clarified extract
    US4927757A|1990-05-22|Production of substantially pure fructose
    CN109180745A|2019-01-11|A method of separating-purifying prepares N-acetyl-neuraminate from the material containing poly sialic acid
    KR960007614B1|1996-06-07|Process for preparation of purified xanthan gum
    RU2035914C1|1995-05-27|Method for producing tuberculin
    同族专利:
    公开号 | 公开日
    CA1244368A|1988-11-08|
    DE3467374D1|1987-12-17|
    NO160620C|1989-05-10|
    AT30742T|1987-11-15|
    FR2551087A1|1985-03-01|
    FR2551087B1|1986-03-21|
    EP0140725A1|1985-05-08|
    NO160620B|1989-01-30|
    EP0140725B1|1987-11-11|
    US4775632A|1988-10-04|
    HUT35282A|1985-06-28|
    NO843417L|1985-03-01|
    HU198530B|1989-10-30|
    RO89834A|1986-07-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    RU2559553C1|2014-07-22|2015-08-10|Маргарита Анатольевна Иванова|Method of producing xanthan|GB1373487A|1970-10-26|1974-11-13|Guggenheim B|Enzymes their preparation and uses|
    US3966618A|1974-03-11|1976-06-29|Merck & Co., Inc.|Clarification of xanthan gum|
    US4094739A|1976-12-27|1978-06-13|The Lubrizol Corporation|Method for purifying microbial polysaccharides|
    EP0039962B1|1980-05-08|1983-03-02|Shell Internationale Researchmaatschappij B.V.|Clarification of polysaccharide-containing fermentation products|
    US4299825A|1980-07-03|1981-11-10|Celanese Corporation|Concentrated xanthan gum solutions|
    DE3172841D1|1980-09-29|1985-12-12|Shell Int Research|Treatment of pseudoplastic polysaccharide solutions|
    FR2506328B1|1981-05-22|1984-01-13|Inst Francais Du Petrole|
    JPS6234013B2|1981-12-29|1987-07-24|Lion Corp|
    JPS6152124B2|1982-02-03|1986-11-12|Rohto Pharma|FR2597503B1|1986-03-10|1988-12-30|Inst Francais Du Petrole|ENZYMATIC PROCESS FOR TREATING XANTHAN GUMS TO IMPROVE THE FILTRABILITY OF THEIR AQUEOUS SOLUTIONS|
    FR2621926B1|1987-10-20|1991-06-21|Inst Francais Du Petrole|PROCESS FOR THE TREATMENT OF A FERMENTATION MUST CONTAINING A POLYSACCHARIDE FOR THE PURPOSE OF INCREASING THE FILTRABILITY AND USE OF THIS ASSIST IN ASSISTED OIL RECOVERY|
    FR2624135B1|1987-12-04|1990-04-13|Rhone Poulenc Chimie|PROCESS FOR PRODUCING POLYSACCHARIDES|
    FR2627509B1|1988-02-18|1990-08-10|Mero Rousselot Satia|TWO-STEP FERMENTATION PROCESS FOR THE PRODUCTION OF POLYSACCHARIDES|
    GB8825181D0|1988-10-27|1988-11-30|Atomic Energy Authority Uk|Recovery of substances|
    DE69221841T2|1991-12-20|1998-01-22|Shinetsu Bio Inc|Process for the production of purified xanthan gum|
    US5595892A|1991-12-20|1997-01-21|Shin-Etsu Chemical Co., Ltd.|Process for preparation of purified xanthan gum|
    US6261547B1|1998-04-07|2001-07-17|Alcon Manufacturing, Ltd.|Gelling ophthalmic compositions containing xanthan gum|
    US6174524B1|1999-03-26|2001-01-16|Alcon Laboratories, Inc.|Gelling ophthalmic compositions containing xanthan gum|
    BR0015256A|1999-11-01|2002-06-18|Alcon Inc|Pharmaceutical compositions containing a fluoroquinolone antibiotic drug and a xanthan gum|
    AU7059301A|2000-07-28|2002-02-13|Alcon Universal Ltd|Pharmaceutical compositions containing tobramycin and xanthan gum|
    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    FR8313885A|FR2551087B1|1983-08-30|1983-08-30|PROCESS FOR TREATING POLYSACCHARIDE SOLUTION AND USE THEREOF|
    [返回顶部]